Tag «Optoacoustic imaging»

Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study

Increase of the efficiency of photodynamic therapy (PDT) requires the development of advanced protocols employing both novel photosensitizer (PS) carriers and aids for online monitoring. Nanoconstructs may be comprised of a photosensitizer, chemotherapy drugs, or inhibitors of molecular pathways that support cancer growth. In this paper, we analyze the efficiency of a bimodal approach involving …

Raster-scan optoacoustic angiography of blood vessel development in colon cancer models

Raster-scan optoacoustic angiography at 532 nm wavelength with 50 μm lateral resolution at 2 mm diagnostic depth was used for quantitative characterization of neoangiogenesis in colon cancer models. Two tumor models of human colon adenocarcinoma (HT-29) and murine colon carcinoma (CT26) different in their histology and vascularization were compared. Tumors of both origins showed an inhomogeneous distribution of areas with high and low vascularization. Rapidly growing CT26 …

Wideband linear detector arrays for optoacoustic imaging based on polyvinylidene difluoride

We provide direct experimental comparison of the optoacoustic imaging performance of two different 64-element linear detector array (LDA) units based on polyvinylidene difluoride (PVDF) films. The first LDA unit was based on traditional flexible circuit (FC) technology and consisted of an FC glued to the nonmetalized signal surface of a 28-μm-thick PVDF film providing 300  /  80-μm …

Fluence compensation in raster-scan optoacoustic angiography

Modern optical imaging techniques demonstrate significant potential for high resolution in vivoangiography. Optoacoustic angiography benefits from higher imaging depth as compared to pure optical modalities. However, strong attenuation of optoacoustic signal with depth provides serious challenges for adequate 3D vessel net mapping, and proper compensation for fluence distribution within biotissues is required. We report on the novel approach allowing …